The Methyl+ at-home genetic test kit for analyzing the methylation cycle.
Methyl+ (Coming Soon)
Methyl+ (Coming Soon)
Methyl+ (Coming Soon)

Genetic Methylation and Nutrient Panel

Methyl+ (Coming Soon)

$425.00

HSA/FSA Eligible

Designed for Men and Women

$425.00 USD
$340.00 USD

Auto-renews, skip or cancel anytime. View subscription policy

To add to cart, go to the product page and select a purchase option

Free delivery & sample return

Fast CLIA-certified lab results in 1-2 days

Painless at-home collection

FDA-cleared collection device

Physician-reviewed results
Methyl+ (Coming Soon) - Genetic Methylation + Nutrient Panel

Your body’s ability to process nutrients, manage stress, and maintain long-term health depends heavily on a process called methylation. This panel looks at 10 key genetic variants (SNPs) that can impact how efficiently your body performs this process, along with lab tests that measure important nutrients that support it.

Methylation plays a role in mood, detox, energy production, and cardiovascular health. When this system is underperforming due to genetic factors or nutrient imbalances, it can lead to fatigue, brain fog, or increased health risks over time. PRYM Methyl+ helps you uncover your unique biology and gives you the insight to support your body more effectively.

What's Tested
  • Genetic Markers: 10-SNP methylation panel
  • Metabolic: Homocysteine
  • Vitamin & Mineral Levels: Vitamin D, B12, Folate, Magnesium
Who It's For
  • Men
  • Women

For those interested in optimizing their health based on their unique genetics, this panel analyzes key genes in the methylation cycle. Your results offer insights into your body's detoxification, energy, and mood regulation pathways.

Kit Includes
  • Easy to understand instructions
  • Collection device with tube
  • Heat pack
  • Bandages
  • Alcohol Swab
  • Prepaid return label and box
Collection Method

This test uses two types of specimens.

Blood: Collected from upper arm using our painless at-home device

Swab: Non-invasive cheek swab

Test Details

Learn more about each test in this panel.

Genetic Markers

10-SNP Methylation Panel
This panel analyzes ten key SNPs (single nucleotide polymorphisms) involved in the methylation cycle—a process essential for detoxification, hormone regulation, neurotransmitter production, and DNA repair. Variants in genes like MTHFR, COMT, and others can affect how efficiently your body uses nutrients like B12 and folate, influencing energy, mood, inflammation, and long-term wellness.

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Homocysteine

Homocysteine
Homocysteine is a compound produced during methylation. Elevated levels can indicate issues in this pathway and may raise the risk of cardiovascular disease, cognitive decline, and chronic inflammation. Monitoring homocysteine is especially important if you have genetic variants affecting methylation.

Vitamin & Mineral Levels

Vitamin D
Essential for immune health, bone strength, and mood balance. Low levels are common in both men and women and can impact hormone levels, energy, and immune resilience.

Vitamin B12
Supports red blood cell formation, nerve function, and mental clarity. It also plays a vital role in methylation. Deficiency can lead to fatigue, brain fog, and mood changes—especially in those with MTHFR or other related variants.

Folate
A key player in methylation and DNA synthesis. Natural folate (not synthetic folic acid) is better utilized by people with MTHFR variants and supports cellular health, detox, and cardiovascular wellness.

Magnesium
An essential mineral involved in over 300 biochemical reactions, including methylation. It supports muscle recovery, sleep, energy production, and stress response—yet it’s one of the most commonly deficient nutrients in adults.

How it Works

Order a test

Select the at-home test that matches your health goals, from hormones to heart health. Not sure where to start? Our 60-second quiz will find your perfect fit.

Take The Quiz

Collect your sample

After a quick online registration, use our painless, FDA-cleared device to collect your sample from home. Simply mail it back the same day using the included free overnight shipping label.

Get your results, fast

Typically within 24 hours of our lab receiving your sample, your physician-reviewed results will be ready. View them in our secure, HIPAA-compliant portal and get health insights you can trust.

FAQs

Please read our FAQs page to find our full list of answers.

How is PRYM different from other at-home tests?

PRYM takes a complete approach to at-home testing focused on accuracy, speed, and quality.

Superior Sample Collection: Our painless, FDA-cleared device collects a high-quality whole blood sample, which is essential for precise results.

In-House Lab: Your sample is processed in our own CLIA-certified sister-company laboratory. This direct connection ensures full quality control, faster turnaround times, and lower costs.

A Complete, Integrated Experience: From collection to results, PRYM delivers a seamless testing process built for accuracy, convenience, and confidence.

How does the at-home collection process work?

It’s simple. Order your preferred test online, collect your sample painlessly at home in minutes, and return it using the included pre-paid overnight label. Your results are delivered securely within days.

Are the results accurate and reliable?

Yes. Every sample is processed in a CLIA-certified laboratory, the same standard used by physicians and hospitals. Our methods are validated against traditional venipuncture collection to ensure results meet the highest level of accuracy and reliability.

Do I need to speak with a doctor?

No, you do not need to speak with a doctor to order or review your results. All results are physician-reviewed for accuracy before being delivered to your secure online portal. We recommend consulting with your healthcare provider if you have questions about your results or before making any changes to your current lifestyle or medications.

Can I use my HSA or FSA card?

Yes. All PRYM at-home test kits are qualified medical expenses and can be purchased using your HSA or FSA card at checkout.

Can I buy a kit as a gift for someone?

Yes. Purchase the kit as you normally would, and the recipient can register the unique Kit ID under their own name when they are ready to collect their sample.

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